Laboratory of Sex/Gender-Informed Translational Neuroscience

Publications

All Publications in PubMed
  • Oken E, Rifas-Shiman SL, Joffe H, Manson JE, Spagnolo PA, Bertisch SM, Klerman EB, Chavarro JE. Associations of adverse childhood and lifetime experiences with sleep quality and duration among women in midlife. Sleep Health. 2023 Dec;9(6):860-867. doi: 10.1016/j.sleh.2023.09.003. PMID: 37923668.
  • Bikdeli B, Muriel A, Wang Y, Piazza G, Khairani CD, Rosovsky RP, Mehdipoor G, O’Donoghue ML, Madridano O, Lopez-Saez JB, Mellado M, Brasero AMD, Grandone E, Spagnolo PA, Lu Y, Bertoletti L, López-Jiménez L, Núñez MJ, Blanco-Molina Á, Gerhard-Herman M, Goldhaber SZ, Bates SM, Jimenez D, Krumholz HM, Monreal M; RIETE Investigators. Sex-Related Differences in Patient Characteristics, Risk Factors, and Symptomatology in Older Adults with Pulmonary Embolism: Findings from the SERIOUS-PE Study. Semin Thromb Hemost. 2023 Oct;49(7):725-735. doi: 10.1055/s-0043-1764231. PMID: 36868268.
  • Spagnolo PA, Johnson K, Hodgkinson C, Goldman D, Hallett M. Methylome changes associated with functional movement/conversion disorder: Influence of biological sex and childhood abuse exposure. Prog Neuropsychopharmacol Biol Psychiatry. 2023 Jul 13;125:110756. doi: 10.1016/j.pnpbp.2023.110756.  PMID: 36958667; PMCID: PMC10205664.
  • Suzuki J, Prostko S, Szpak V, Chai PR, Spagnolo PA, Tenenbaum RE, Ahmed S, Weiss RD. Impact of cannabidiol on reward- and stress-related neurocognitive processes among individuals with opioid use disorder: A pilot, double-blind, placebo-controlled, randomized cross-over trial. Front Psychiatry. 2023 Mar 30;14:1155984. doi: 10.3389/fpsyt.2023.1155984. PMID: 37065899; PMCID: PMC10098189.
  • Spagnolo PA, Lorell BH, Joffe H. Preface to theme issue on women’s health and clinical trials. Contemp Clin Trials. 2022 Jun 18;119:106837. doi: 10.1016/j.cct.2022.106837. PMID: 35728741.
  • Montemitro C, Cavallotto C, Giovannetti G, Martino F, Pasino A, Vicinelli MC, Fraticelli S, Di Giannantonio M, Spagnolo PA. Analysis of female enrollment in clinical trials for alcohol and substance use disorders: Is it time for sex- informed pharmacotherapy? Contemp Clin Trials. 2022 Jul;118:106784. doi: 10.1016/j.cct.2022.106784. PMID: 35618230.
  • Sosinsky AZ, Rich-Edwards JW, Wiley A, Wright K, Spagnolo PA, Joffe H. Enrollment of female participants in United States drug and device phase 1-3 clinical trials between 2016 and 2019. Contemp Clin Trials. 2022 Apr;115:106718. doi: 10.1016/j.cct.2022.106718. PMID: 35247632.
  • Martinotti G, Pettorruso M, Montemitro C, Spagnolo PA, Acuti Martellucci C, Di Carlo F, Fanella F, di Giannantonio M; Brainswitch Study Group. Repetitive transcranial magnetic stimulation in treatment-seeking subjects with cocaine use disorder: A randomized, double-blind, sham-controlled trial. Prog Neuropsychopharmacol Biol Psychiatry. 2022 Jun 8;116:110513. doi: 10.1016/j.pnpbp.2022.110513. PMID: 35074451.
  • Spagnolo PA, Parker J, Horovitz S, Hallett M. Corticolimbic Modulation via Intermittent Theta Burst Stimulation as a Novel Treatment for Functional Movement Disorder: A Proof-of-Concept Study. Brain Sci. 2021 Jun 15;11(6):791. doi: 10.3390/brainsci11060791. PMID: 34203993; PMCID: PMC8232716.
  • Spagnolo PA, Garvey M, Hallett M. A dimensional approach to functional movement disorders: Heresy or opportunity. Neurosci Biobehav Rev. 2021 Aug;127:25-36. doi: 10.1016/j.neubiorev.2021.04.005. PMID: 33848511; PMCID: PMC8292172.
  • Spagnolo PA, Manson JE, Joffe H. Sex and Gender Differences in Health. Ann Intern Med. 2021 Jan;174(1):143-144. doi: 10.7326/L20-1374. PMID: 33460539.
  • Spagnolo PA, Montemitro C, Leggio L. New Challenges in Addiction Medicine: COVID-19 Infection in Patients With Alcohol and Substance Use Disorders-The Perfect Storm. Am J Psychiatry. 2020 Sep 1;177(9):805-807. doi: 10.1176/appi.ajp.2020.20040417. PMID: 32660296.
  • Spagnolo PA, Norato G, Maurer CW, Goldman D, Hodgkinson C, Horovitz S, Hallett M. Effects of TPH2 gene variation and childhood trauma on the clinical and circuit-level phenotype of functional movement disorders. J Neurol Neurosurg Psychiatry. 2020 Aug;91(8):814-821. doi: 10.1136/jnnp-2019-322636. PMID: 32576619; PMCID: PMC7402460.
  • Spagnolo PA, Manson JE, Joffe H. Sex and Gender Differences in Health: What the COVID-19 Pandemic Can Teach Us. Ann Intern Med. 2020 Sep 1;173(5):385-386. doi: 10.7326/M20-1941 PMID: 32384135; PMCID: PMC7249504.
  • Spagnolo PA, Montemitro C, Pettorruso M, Martinotti G, Di Giannantonio M. Better Together? Coupling Pharmacotherapies and Cognitive Interventions With Non-invasive Brain Stimulation for the Treatment of Addictive Disorders. Front Neurosci. 2020 Jan 10;13:1385. doi: 10.3389/fnins.2019.01385. PMID: 31998061; PMCID: PMC6967837.
  • Pettorruso M, Martinotti G, Montemitro C, De Risio L, Spagnolo PA, Gallimberti L, Fanella F, Bonci A, Di Giannantonio M; Brainswitch Study Group. Multiple Sessions of High-Frequency Repetitive Transcranial Magnetic Stimulation as a Potential Treatment for Gambling Addiction: A 3-Month, Feasibility Study. Eur Addict Res. 2020;26(1):52-56. doi: 10.1159/000504169. PMID: 31665732.
  • Ekhtiari H, Tavakoli H, Addolorato G, Baeken C, Bonci A, Campanella S, Castelo-Branco L, Challet-Bouju G, Clark VP, Claus E, Dannon PN, Del Felice A, den Uyl T, Diana M, di Giannantonio M, Fedota JR, Fitzgerald P, Gallimberti L, Grall-Bronnec M, Herremans SC, Herrmann MJ, Jamil A, Khedr E, Kouimtsidis C, Kozak K, Krupitsky E, Lamm C, Lechner WV, Madeo G, Malmir N, Martinotti G, McDonald WM, Montemitro C, Nakamura-Palacios EM, Nasehi M, Noël X, Nosratabadi M, Paulus M, Pettorruso M, Pradhan B, Praharaj SK, Rafferty H, Sahlem G, Salmeron BJ, Sauvaget A, Schluter RS, Sergiou C, Shahbabaie A, Sheffer C, Spagnolo PA, Steele VR, Yuan TF, van Dongen JDM, Van Waes V, Venkatasubramanian G, Verdejo-García A, Verveer I, Welsh JW, Wesley MJ, Witkiewitz K, Yavari F, Zarrindast MR, Zawertailo L, Zhang X, Cha YH, George TP, Frohlich F, Goudriaan AE, Fecteau S, Daughters SB, Stein EA, Fregni F, Nitsche MA, Zangen A, Bikson M, Hanlon CA. Transcranial electrical and magnetic stimulation (tES and TMS) for addiction medicine: A consensus paper on the present state of the science and the road ahead. Neurosci Biobehav Rev. 2019 Sep;104:118-140. doi: 10.1016/j.neubiorev.2019.06.007. PMID: 31271802; PMCID: PMC7293143.
  • Spagnolo PA, Kimes A, Schwandt ML, Shokri-Kojori E, Thada S, Phillips KA, Diazgranados N, Preston KL, Herscovitch P, Tomasi D, Ramchandani VA, Heilig M. Striatal Dopamine Release in Response to Morphine: A [11C]Raclopride Positron Emission Tomography Study in Healthy Men. Biol Psychiatry. 2019 Sep 1;86(5):356-364. doi: 10.1016/j.biopsych.2019.03.965. PMID: 31097294; PMCID: PMC6699765.
  • Spagnolo PA, Gómez Pérez LJ, Terraneo A, Gallimberti L, Bonci A. Neural correlates of cue- and stress-induced craving in gambling disorders: implications for transcranial magnetic stimulation interventions. Eur J Neurosci. 2019 Aug;50(3):2370-2383. doi: 10.1111/ejn.14313. PMID: 30575160.
  • Spagnolo PA, Wang H, Srivanitchapoom P, Schwandt M, Heilig M, Hallett M. Lack of Target Engagement Following Low-Frequency Deep Transcranial Magnetic Stimulation of the Anterior Insula. Neuromodulation. 2019 Dec;22(8):877-883. doi: 10.1111/ner.12875. PMID: 30370983; PMCID: PMC6488455.
  • Mayo LM, Asratian A, Lindé J, Holm L, Nätt D, Augier G, Stensson N, Vecchiarelli HA, Balsevich G, Aukema RJ, Ghafouri B, Spagnolo PA, Lee FS, Hill MN, Heilig M. Protective effects of elevated anandamide on stress and fear- related behaviors: translational evidence from humans and mice. Mol Psychiatry. 2020 May;25(5):993-1005. doi: 10.1038/s41380-018-0215-1. PMID: 30120421.
  • Pettorruso M, Spagnolo PA, Leggio L, Janiri L, Di Giannantonio M, Gallimberti L, Bonci A, Martinotti G. Repetitive transcranial magnetic stimulation of the left dorsolateral prefrontal cortex may improve symptoms of anhedonia in individuals with cocaine use disorder: A pilot study. Brain Stimul. 2018 Sep-Oct;11(5):1195-1197. doi: 10.1016/j.brs.2018.06.001. PMID: 29885861.
  • Landefeld CC, Hodgkinson CA,Spagnolo PA, Marietta CA, Shen PH, Sun H, Zhou Z, Lipska BK, Goldman D. Effects on gene expression and behavior of untagged short tandem repeats: the case of arginine vasopressin receptor 1a (AVPR1a) and externalizing behaviors. Transl Psychiatry. 2018 Mar 27;8(1):72. doi: 10.1038/s41398-018-0120-z. PMID: 29581423; PMCID: PMC5913313.
  • Grodin EN, Cortes CR, Spagnolo PA, Momenan R. Structural deficits in salience network regions are associated with increased impulsivity and compulsivity in alcohol dependence. Drug Alcohol Depend. 2017 Oct 1;179:100-108. doi: 10.1016/j.drugalcdep.2017.06.014. PMID: 28763777.
  • Case LK, Laubacher CM, Richards EA, Spagnolo PA, Olausson H, Bushnell MC. Inhibitory rTMS of secondary somatosensory cortex reduces intensity but not pleasantness of gentle touch. Neurosci Lett. 2017 Jul 13;653:84-91. doi: 10.1016/j.neulet.2017.05.006. PMID: 28529174; PMCID: PMC5530593.
  • Sloan ME, Gowin JL, Yan J, Schwandt ML, Spagnolo PA, Sun H, Hodgkinson CA, Goldman D, Ramchandani VA. Severity of alcohol dependence is associated with the fatty acid amide hydrolase Pro129Thr missense variant. Addict Biol. 2018 Jan;23(1):474-484. doi: 10.1111/adb.12491. PMID: 28150397; PMCID: PMC5538894.
  • Spagnolo PA, Goldman D. Neuromodulation interventions for addictive disorders: challenges, promise, and roadmap for future research. Brain. 2017 May 1;140(5):1183-1203. doi: 10.1093/brain/aww284. PMID: 28082299; PMCID: PMC6059187.
  • Spagnolo PA, Ramchandani VA, Schwandt ML, Kwako LE, George DT, Mayo LM, Hillard CJ, Heilig M. FAAH Gene Variation Moderates Stress Response and Symptom Severity in Patients with Posttraumatic Stress Disorder and Comorbid Alcohol Dependence. Alcohol Clin Exp Res. 2016 Nov;40(11):2426-2434. doi: 10.1111/acer.13210. PMID: 27716956; PMCID: PMC5748341.
  • Case LK, Laubacher CM, Olausson H, Wang B, Spagnolo PA, Bushnell MC. Encoding of Touch Intensity But Not Pleasantness in Human Primary Somatosensory Cortex. J Neurosci. 2016 May 25;36(21):5850-60. doi: 10.1523/JNEUROSCI.1130-15.2016. PMID: 27225773; PMCID: PMC4879201.
  • Spagnolo PA, Colloca L, Heilig M. The role of expectation in the therapeutic outcomes of alcohol and drug addiction treatments. Alcohol Alcohol. 2015 May;50(3):282-5. doi: 10.1093/alcalc/agv015. PMID: 25761920; PMCID: PMC4415067.
  • Spagnolo PA, Ramchandani VA, Schwandt ML, Zhang L, Blaine SK, Usala JM, Diamond KA, Phillips MJ, George DT, Momenan R, Heilig M. Effects of naltrexone on neural and subjective response to alcohol in treatment-seeking alcohol- dependent patients. Alcohol Clin Exp Res. 2014 Dec;38(12):3024-32. doi: 10.1111/acer.12581. PMID: 25581657; PMCID: PMC4293087.
  • Kwako LE,Spagnolo PA, Schwandt ML, Thorsell A, George DT, Momenan R, Rio DE, Huestis M, Anizan S, Concheiro M, Sinha R, Heilig M. The corticotropin releasing hormone-1 (CRH1) receptor antagonist pexacerfont in alcohol dependence: a randomized controlled experimental medicine study. Neuropsychopharmacology. 2015 Mar 13;40(5):1053-63. doi: 10.1038/npp.2014.306. PMID: 25409596; PMCID: PMC4367465.
  • Kwako LE, George DT, Schwandt ML, Spagnolo PA, Momenan R, Hommer DW, Diamond CA, Sinha R, Shaham Y, Heilig M. The neurokinin-1 receptor antagonist aprepitant in co-morbid alcohol dependence and posttraumatic stress disorder: a human experimental study. Psychopharmacology (Berl). 2015 Jan;232(1):295-304. doi: 10.1007/s00213-014-3665-4. PMID: 25030801; PMCID: PMC4512162.
  • Spagnolo PA, Badiani A, Nencini P. Polydrug abuse by intravenous use of heroin and tropicamide-containing eyedrops. Clin Neuropharmacol. 2013 May- Jun;36(3):100-1. doi: 10.1097/WNF.0b013e31828da20e. PMID: 23673915.
  • Badiani A, Spagnolo PA. Role of environmental factors in cocaine addiction. Curr Pharm Des. 2013;19(40):6996-7008. doi: 10.2174/1381612819999131125221238. PMID: 23574438.
  • De Luca MT, Meringolo M, Spagnolo PA, Badiani A. The role of setting for ketamine abuse: clinical and preclinical evidence. Rev Neurosci. 2012;23(5-6):769-80. doi: 10.1515/revneuro-2012-0078. PMID: 23159868.
  • Fiorentino D, Coriale G,Spagnolo PA, Prastaro A, Attilia ML, Mancinelli R, Ceccanti M. Fetal alcohol syndrome disorders: experience on the field. The Lazio study preliminary report. Ann Ist Super Sanita. 2006;42(1):53-7. PMID: 16801726.
  • Calhoun F, Attilia ML, Spagnolo PA, Rotondo C, Mancinelli R, Ceccanti M. National Institute on Alcohol Abuse and Alcoholism and the study of fetal alcohol spectrum disorders. The International Consortium. Ann Ist Super Sanita. 2006;42(1):4-7. PMID: 16801719.
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